Anti-Aging Hormone Therapy - Which Hormones Make You Look Younger?

Jenna Hilton
May 12, 2022

Aging signs like fine lines and wrinkles, dry skin, decreased skin elasticity, and hair loss are also caused by changes in hormone levels. The good news is that you can rejuvenate your appearance with hormone replacement therapy.

This article explains which hormones make people look older and how anti-aging hormone therapy can help restore a youthful look.

Anti aging hormone therapy: which hormones make you look younger?

What Is Anti-Aging Hormone Therapy?

Anti-aging hormone therapy is hormone replacement therapy (HRT) that improves the levels of those hormones which cause aging signs. Certain hormonal shifts accelerate the aging process and manifest as:

  • Loss of collagen and elastin
  • Thinning skin
  • Dry skin
  • Increased wrinkling
  • Pigmentary changes
  • Weight gain
  • Hair thinning and hair loss
  • Impaired wound healing
  • Decreased muscle mass
  • Lower energy levels

HRT is usually administered to women in menopause and men in andropause.

Can Hormone Therapy Reverse Aging?

Hormone replacement therapy can reverse aging signs by increasing epidermal hydration, stimulating the production of collagen and elastin, improving skin elasticity and thickness, and reducing fine lines and wrinkles.

Improved hormonal levels can also increase energy and alleviate mood swings, making you feel younger.

Which Hormones Help Maintain a Younger Look?

Hormone replacement therapy can be given as a pill, injection, or topical product. The treatment often includes a combination of different hormones, depending on which hormones the patient lacks or has in excess. The medical provider takes a blood test and assesses the patient’s hormonal status to create a comprehensive and targeted HRT treatment plan.

Our medical professionals at the Vibrant Vitality Clinic use specially formulated bioidentical combinations in their anti-aging hormone replacement treatments to address each patient’s specific health issues and skin concerns.

The following hormones are usually used in anti-aging hormone replacement therapy.


Estrogen is responsible for the functioning of our metabolism, muscle growth, energy levels, skin, nails, and hair. It’s generally considered a female hormone but is also present in low amounts in men.

Estrogen has over 400 functions in women’s bodies, and its deficiency can trigger numerous health conditions and accelerate aging.

In skin physiology, estrogen regulates:

  • Keratinocytes responsible for skin growth and structure
  • Fibroblasts responsible for wound healing
  • Melanocytes which produce skin pigment
  • Sebaceous glands responsible for producing sebum to protect the skin

Women typically experience estrogen deficiency in menopause. Lower levels of this hormone lead to thinning, sagging, and dryness of skin, more pronounced wrinkles, and pigmentation issues.

Female hormone replacement therapy balances estrogen levels and restores the hormone’s functions, preventing or reversing aging signs.


Progesterone is a “female” hormone involved in regulating the menstrual cycle and supporting pregnancy. It is also present in men to a lesser degree.

Women experience progesterone fluctuations throughout life, with levels rising around ovulation and falling if the egg remains unfertilized. Prolonged progesterone deficiency leads to high cortisol and low estrogen. The resulting disbalance increases aging signs such as wrinkles, dry and sagging skin. Excessive levels of progesterone can cause sebum build-up and breakouts.

Anti-aging hormone treatments help balance progesterone levels, alleviating aging symptoms.


Like estrogen, testosterone regulates numerous bodily functions. In skin physiology, testosterone affects collagen and sebum production and, consequently, skin thickness and moisture levels. Loss of testosterone leads to dry and thinning skin, while excessive testosterone production can cause acne.

In menopause, women experience a rise in testosterone levels and a drop in estrogen, while men experience the reverse. Testosterone replacement therapies can help both men and women achieve optimal levels of this hormone.

Note: Learn more about what is Testosterone therapy and how does it work in our detailed article.

Human Growth Hormone (HGH)

HGH is usually used for treating dwarfism in children because it is responsible for muscle and bone growth.

Its levels decrease with age, causing aging signs such as wrinkles, thinning lips, and joint pain. Medical professionals recommend boosting HGH levels with exercise, a protein-rich diet, and getting enough sleep. Patients with human growth hormone deficiency can also benefit from HGH injections.


Cortisol is a stress hormone produced by the adrenal glands. People who go through prolonged periods of stress can also experience cortisol-induced collagen loss, resulting in dull, sagging skin. Cortisol levels can be regulated with anti-aging HRT treatments, resulting in a slowing down of skin aging.


Hormone replacement therapy positively affects our appearance because it helps prevent or reverse the signs of aging.

Consult an experienced medical professional before seeking hormone replacement therapy to learn which hormones you need to supplement to look and feel better.

Jenna Hilton
Jenna Hilton has been a practicing PA since 2009, specializing in Family, Internal Medicine and Medical Aesthetics. She attended Arizona State University where she received her Bachelor's Degree and graduated magna cum laude. She received her Master of Science degree in Physician Assistant Studies from A.T. Still University.

Jenna has been injecting neurotoxin and dermal filler since 2013. She received certification as a Master Injector in 2017 through Empire Medical in Los Angeles, California. She is currently working on a Fellowship Program in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine. Her special interests include use of PLLA, Ablative/Non ablative skin resurfacing, PDO threads, hormone therapy and nutritional therapies to improve cellular regeneration and medically supervised weight loss.

Jenna Hilton believes in a multi-factorial approach, considering internal factors that accelerate aging and disease development. She always enjoys teaching. She co-founded Vibrant EDU courses at Vibrant Skin Bar and regularly performs one-on-one training with fellow injectors. She teaches Aesthetic and Advanced Injectable Courses at National Laser Institute. She has been named Preceptor of the Year and is an Adjunct Faculty Member at Midwestern University. She was born in Iowa, and lives with her husband and three children in Phoenix, AZ.

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