Hormone Replacement Therapy and Weight Loss: How Are They Related?

Jenna Hilton
July 6, 2023

Imbalanced hormones have many unpleasant symptoms, including weight gain. Disrupted hormone levels destabilize sugar levels, slow down metabolism, and increase fat storage.

Both men and women can be affected by this problem. However, women are particularly prone to weight gain during menopause, when hormonal shifts contribute to weight oscillations and imbalanced fat distribution.

Hormone replacement therapy (HRT) offers an effective solution for shedding extra pounds. Read about 13 ways hormone replacement therapy can help with weight loss.

Hormone replacement therapy and weight loss.

13 Ways Hormone Replacement Therapy (HRT) Aids Weight Loss

Hormonal weight gain can be caused by a number of health conditions. Medical weight loss programs can integrate hormone replacement therapy to accelerate weight loss and yield better and more sustainable results.

These are the ways hormonal replacement therapy can help you lose weight:

1. Improves Body Composition

Hormone deficiencies contribute to rapid muscle loss and uneven fat distribution, creating an unhealthy body composition. Menopausal women tend to store more fat, especially around the waistline, forming the so-called “meno-pot.” Getting rid of hormonal belly fat can be daunting but isn’t impossible.

Hormone replacement therapy improves body composition by elevating estrogen levels to speed up metabolism and change how and where the body distributes fat. Balancing testosterone levels helps increase muscle mass and promotes muscle growth as this androgen is responsible for muscle protein synthesis.

Note: Find out more about how testosterone therapy makes you lose weight.

2. Speeds Up Metabolism

Lack of estrogen during perimenopause and menopause can slow down metabolism, the chemical processes that convert food into energy.

Hormone replacement therapy boosts metabolic rate, improving the body’s ability to burn calories more efficiently and lose excess weight. Bioidentical estrogen can increase basal metabolic rate (BMR), preventing unwanted weight gain by regulating blood sugar and how the body processes starches.

3. Regulates Insulin Levels

Estrogen deficiency makes the cells less responsive to insulin and can lead to a medical condition known as insulin resistance. Reduced sensitivity to insulin prevents the conversion of glucose into energy, causing weight problems and increasing the risk of developing diabetes.

Hormone replacement therapy can help you lose weight by optimizing insulin secretion to secure healthy levels of sugar in the blood (glucose) and prevent fat accumulation.

Note: Check out these 14 best weight loss products and learn how to use them to customize your fitness program.

4. Reduces Cravings

Hormone replacement therapy can curb your appetite, reduce unhealthy cravings, and prevent emotional overeating by tackling estrogen imbalances.

Estrogen works as an appetite suppressant, similarly to leptin, signaling to the brain when you are full. It regulates appetite and lowers the risk of menopausal weight fluctuations, preventing the development of leptin resistance.

Moreover, estrogen modulates ghrelin, the “hunger hormone” responsible for food intake. Optimal hormonal activity improves our chances of slimming down by making it easier to stop when we are full and helping us avoid high-calorie junk food.

Note: Vibrant Crave Control supplement has appetite-suppressing properties to help you get back into shape.

5. Minimizes Water Retention

Dysfunctional hormonal activity during perimenopause, characterized by high estrogen and low progesterone, may result in excess fluid accumulation and swelling. Progesterone is a natural diuretic so when levels drop, the body retains water in the tissues. Furthermore, in menopause, drops in estrogen can trigger bloating due to decreased bile production.

Hormone replacement therapy can alleviate water retention symptoms. When optimal levels of estrogen and progesterone are restored, water is evenly distributed in organs and tissues, and the body produces healthy levels of bile, reducing menopausal constipation and bloating.

Note: Learn how to trim down with these 19 practical weight loss tips.

6. Supports Thyroid Function

An underactive thyroid, or hypothyroidism, contributes to weight gain by lowering metabolic rate and reducing fat burn. Irregular hormonal activity during perimenopause and menopause can affect thyroid function, leading to excess fat accumulation.

Hormone replacement therapy can restore thyroid functionality by optimizing estrogen levels.

Note: Vibrant Thyroid Support can restore healthy thyroid activity to speed up your weight loss.

7. Targets Adrenal Imbalances

High cortisol levels triggered by chronic stress correlate with bigger waist circumference and obesity. Moreover, adrenal depletion causes tiredness and a lack of motivation to exercise, creating a vicious cycle for overweight patients.

Note: Find out how to lower cortisol levels naturally.

Hormone replacement therapy can alleviate symptoms of adrenal fatigue, including excess weight, by rebalancing adrenal hormone levels.

8. Optimizes Gut Health

An impaired gut microbiome hinders digestion, energy expenditure, and nutrient absorption needed for sustaining optimal weight. Additionally, poor gut microbiota may disrupt the appetite-controlling hormones leptin and ghrelin, leading to higher caloric absorption and increased fat storage.

Menopausal drops in estrogen can reduce gut microbial diversity, resulting in poor metabolization of fats and lipids. By replacing estrogen and progesterone, HRT can prevent gut microbial imbalance and counteract unwanted weight fluctuations. Improving gut health has a significant impact on overall hormonal status and the likelihood of staying fit.

Note: Use Vibrant GUT SUPPORT to maintain and improve your gastrointestinal health.

9. Boosts Energy Levels

Reducing weight is only possible by sustaining energy resources. This is something that hormone replacement therapy can provide, creating a positive loop. Energetic people are more likely to exercise and move their body to stay in shape or make healthier food choices.

HRT, such as bioidentical hormone replacement therapy or testosterone therapy, can boost energy to increase physical stamina, fitness, and endurance. Testosterone stimulates neurotransmitters, such as dopamine, to support energy production, while estrogen promotes physical activity, energy expenditure, and better fat distribution.

Note: Read about all the benefits of testosterone therapy in our blog article.

10. Reduces Inflammation

While chronic inflammation does not directly cause weight gain, it creates an environment that hampers healthy weight management by:

  • Increasing insulin resistance
  • Slowing down metabolic rate
  • Promoting visceral fat storage
  • Disrupting appetite-regulating hormones

Hormone replacement therapy can suppress long-term inflammatory processes to support your weight loss regime.

Note: Find out more about how to reduce inflammation to manage your weight.

11. Regulates Body Temperature Regulation

Menopausal hot flashes and night sweats are among the first symptoms of hormonal imbalance. Frequent shifts in body temperature can interfere with one’s workout schedule and come in the way of achieving and maintaining desired weight goals. Inconsistent or reduced physical activity during this uncomfortable period may lead to chronic fatigue, a high-calorie diet, and packing on the pounds.

Hormone replacement therapy can help regulate body temperature by restoring optimal levels of estrogen, progesterone, and testosterone. These hormones send signals to the hypothalamus – the brain region responsible for thermoregulation.

12. Contributes to Sleep Quality

Getting enough rest reduces the risk of becoming overweight during big hormonal shifts. Sleep deprivation is heavily associated with a higher body mass index (BMI) and obesity. Deep, restorative sleep aids weight management by:

  • Maintaining a healthy metabolic rate
  • Regulating leptin and ghrelin levels
  • Reducing unhealthy cravings
  • Lowering stress hormones
  • Supporting blood sugar control
  • Aiding muscle recovery

Testosterone therapy can resolve sleep disturbances, such as hormonal insomnia, triggered by low testosterone levels. HRT improves sleep quality by optimizing estrogen and progesterone levels which facilitate falling asleep, boost the REM phase, and strengthen sleep cycles.

Note: Read about what sleep-supporting benefits Relora, a natural herbal supplement, provides.

13. Improves Mood

Hormonal fluctuations can cause mood swings, anxiety, and depression, making it more difficult to make healthy food choices or stick to a consistent exercise schedule. Lack of motivation dampens the mood for any physical activity essential for staying healthy and fit.

Hormone replacement therapy balances out estrogen, progesterone, and testosterone to alleviate mood-related symptoms, such as irritability, nervousness, or anxiety. HRT also helps stabilize serotonin levels, fostering a positive attitude toward a healthier lifestyle and better chances of shedding excess weight.

Note: You can boost your mood with these 10 vitamins and supplements for hormone balancing.

Other Notable Benefits of Hormone Replacement Therapy

In addition to supporting sustained weight management, HRT provides other health benefits, such as:


Hormone replacement therapy is a highly individualized program tailored for each patient’s unique hormonal profile. It targets specific hormonal factors that contribute to unwanted weight changes.

Vibrant Vitality Clinic offers some of the best HRT for weight loss, such as female bioidentical HRT ($249) and male HRT hormone therapy ($249).

Each package includes a 45-minute consultation, a physical examination, and a 30-minute follow-up session.

Jenna Hilton
Jenna Hilton has been a practicing PA since 2009, specializing in Family, Internal Medicine and Medical Aesthetics. She attended Arizona State University where she received her Bachelor's Degree and graduated magna cum laude. She received her Master of Science degree in Physician Assistant Studies from A.T. Still University.

Jenna has been injecting neurotoxin and dermal filler since 2013. She received certification as a Master Injector in 2017 through Empire Medical in Los Angeles, California. She is currently working on a Fellowship Program in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine. Her special interests include use of PLLA, Ablative/Non ablative skin resurfacing, PDO threads, hormone therapy and nutritional therapies to improve cellular regeneration and medically supervised weight loss.

Jenna Hilton believes in a multi-factorial approach, considering internal factors that accelerate aging and disease development. She always enjoys teaching. She co-founded Vibrant EDU courses at Vibrant Skin Bar and regularly performs one-on-one training with fellow injectors. She teaches Aesthetic and Advanced Injectable Courses at National Laser Institute. She has been named Preceptor of the Year and is an Adjunct Faculty Member at Midwestern University. She was born in Iowa, and lives with her husband and three children in Phoenix, AZ.

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